| Bryan Cranston | ... | Walter White (62 episodes, 2008-2013) |
| Anna Gunn | ... | Skyler White (62 episodes, 2008-2013) |
| Aaron Paul | ... | Jesse Pinkman (62 episodes, 2008-2013) |
| Dean Norris | ... | Hank Schrader (62 episodes, 2008-2013) |
| Betsy Brandt | ... | Marie Schrader (62 episodes, 2008-2013) |
| RJ Mitte | ... | Walter White, Jr. (62 episodes, 2008-2013) |
| Bob Odenkirk | ... | Saul Goodman (43 episodes, 2009-2013) |
| Steven Michael Quezada | ... | Steven Gomez (33 episodes, 2008-2013) |
| Jonathan Banks | ... | Mike Ehrmantraut (28 episodes, 2009-2012) |
| Giancarlo Esposito | ... | Gustavo 'Gus' Fring (26 episodes, 2009-2011) |
| Charles Baker | ... | Skinny Pete (14 episodes, 2008-2013) |
| Christopher Cousins | ... | Ted Beneke (13 episodes, 2009-2012) |
| Laura Fraser | ... | Lydia Rodarte-Quayle (12 episodes, 2012-2013) |
| Jesse Plemons | ... | Todd (12 episodes, 2012-2013) |
| Matt Jones | ... | Badger (12 episodes, 2008-2013) |
| Michael Shamus Wiles | ... | ASAC George Merkert (11 episodes, 2009-2012) |
| Lavell Crawford | ... | Huell (11 episodes, 2011-2013) |
| Ray Campbell | ... | Tyrus Kitt (10 episodes, 2011) |
| Krysten Ritter | ... | Jane Margolis (10 episodes, 2009-2010) |
| Emily Rios | ... | Andrea Cantillo (10 episodes, 2010-2013) |
| Ian Posada | ... | Brock Cantillo (10 episodes, 2010-2013) |
| Tina Parker | ... | Francesca (9 episodes, 2009-2013) |
| Carmen Serano | ... | Carmen Molina (9 episodes, 2008-2013) |
| Mark Margolis | ... | Tio Salamanca (8 episodes, 2009-2011) |
| Jeremiah Bitsui | ... | Victor (8 episodes, 2009-2011) |
| David Costabile | ... | Gale Boetticher (7 episodes, 2010-2011) |
| David House | ... | Dr. Delcavoli (7 episodes, 2008-2009) |
| Daniel Moncada | ... | Leonel Salamanca (6 episodes, 2010) |
| Michael Bowen | ... | Uncle Jack (6 episodes, 2012-2013) |
| Kevin Rankin | ... | Kenny (6 episodes, 2012-2013) |
| Bill Burr | ... | Kuby (5 episodes, 2011-2013) |
| Marius Stan | ... | Bogdan Wolynetz (5 episodes, 2008-2011) |
| Rodney Rush | ... | Combo (5 episodes, 2008-2010) |
| Luis Moncada | ... | Marco Salamanca (5 episodes, 2010) |
| Kaija Bales | ... | Kaylee Ehrmantraut (5 episodes, 2010-2012) |
| Matthew T. Metzler | ... | Matt / ... (5 episodes, 2013) |
| Todd Terry | ... | SAC Ramey (5 episodes, 2009-2013) |
| Patrick Sane | ... | Frankie (5 episodes, 2012-2013) |
| Raymond Cruz | ... | Tuco Salamanca (4 episodes, 2008-2009) |
| Tess Harper | ... | Mrs. Pinkman (4 episodes, 2008-2010) |
| John de Lancie | ... | Donald Margolis (4 episodes, 2009-2010) |
| Fred Cruz | ... | Lt. Adam Estiguez (4 episodes, 2009-2012) |
| Jere Burns | ... | Group Leader (4 episodes, 2010-2011) |
| Nigel Gibbs | ... | APD Detective Tim Roberts (4 episodes, 2009-2011) |
| Tom Kiesche | ... | Clovis (4 episodes, 2009-2010) |
| Maurice Compte | ... | Gaff (4 episodes, 2011) |
| Morse Bicknell | ... | Declan's Driver (4 episodes, 2012-2013) |
| Jessica Hecht | ... | Gretchen Schwartz (4 episodes, 2008-2013) |
| Tait Fletcher | ... | Lester (4 episodes, 2013) |
| Christopher King | ... | Chris Mara (4 episodes, 2011-2012) |
| Max Arciniega | ... | Krazy-8 (3 episodes, 2008) |
| Michael Bofshever | ... | Mr. Pinkman (3 episodes, 2008-2010) |
| Julie Dretzin | ... | Pamela (3 episodes, 2010) |
| Jesus Jr. | ... | No-Doze / ... (3 episodes, 2008-2009) |
| Louis Ferreira | ... | Declan (3 episodes, 2012-2013) |
| Cesar Garcia | ... | Gonzo / ... (3 episodes, 2008-2009) |
| Julia Minesci | ... | Wendy (3 episodes, 2008-2010) |
| Mike Batayeh | ... | Dennis Markowski (3 episodes, 2011-2012) |
| Javier Grajeda | ... | Juan Bolsa (3 episodes, 2010-2011) |
| Angelo Martinez | ... | Tomas / ... (3 episodes, 2009-2010) |
| Gonzalo Menendez | ... | Detective Kalanchoe (3 episodes, 2011-2013) |
| Chris Freihofer | ... | Dan Wachsberger (3 episodes, 2012) |
| Mike Seal | ... | Rival Dealer #1 (3 episodes, 2009-2010) |
| Ashley Kajiki | ... | Pollos Manager / ... (3 episodes, 2009-2011) |
| Mary Sue Evans | ... | Janice (3 episodes, 2010-2013) |
| Jason Douglas | ... | Detective Munn (3 episodes, 2011-2013) |
| Antonio Leyba | ... | Rival Dealer #2 (3 episodes, 2009-2010) |
| Christopher Dempsey | ... | ER Doctor #1 / ... (3 episodes, 2008-2010) |
| Karen M. Hudson | ... | Office Worker (3 episodes, 2009-2010) |
| Jamie Haqqani | ... | DEA Agent (3 episodes, 2009) |
| John Koyama | ... | Emilio Koyama (2 episodes, 2008) |
| Danny Trejo | ... | Tortuga (2 episodes, 2009-2010) |
| Dale Dickey | ... | Spooge's Woman (2 episodes, 2009) |
| David Ury | ... | Spooge (2 episodes, 2009) |
| Jim Beaver | ... | Lawson (2 episodes, 2011-2012) |
| Sam McMurray | ... | Dr. Victor Bravenec (2 episodes, 2009) |
| Dan Desmond | ... | Mr. Gardiner (2 episodes, 2009-2010) |
| Jeremy Howard | ... | Sketchy (2 episodes, 2011) |
| Larry Hankin | ... | Old Joe (2 episodes, 2010-2012) |
| JB Blanc | ... | Dr. Barry Goodman (2 episodes, 2011-2012) |
| Jason Byrd | ... | Ben / ... (2 episodes, 2008) |
| James Ning | ... | Duane Chow (2 episodes, 2010-2012) |
| Russ Dillen | ... | Ron Forenall (2 episodes, 2012) |
| Jonathan Ragsdale | ... | Barry (2 episodes, 2009-2010) |
| Steven Bauer | ... | Don Eladio (2 episodes, 2011) |
| Sam Webb | ... | Drew Sharp (2 episodes, 2012) |
| Judith Rane | ... | Office Manager (2 episodes, 2008-2009) |
| Catherine Haun | ... | Receptionist (2 episodes, 2009-2010) |
| Caleb Landry Jones | ... | Louis (2 episodes, 2009-2010) |
| Virginia Montero | ... | Grandma (2 episodes, 2010-2011) |
| Eric Steinig | ... | Mike's Security Team 2 / ... (2 episodes, 2011) |
| Pedro GarcÃa | ... | Mariano (2 episodes, 2013) |
| Phil Duran | ... | DEA Agent / ... (2 episodes, 2012-2013) |
| Antoinette Antonio | ... | TV Reporter (2 episodes, 2012) |
| Miguel Martinez | ... | Fernando (2 episodes, 2012) |
| John Christopher Hicks | ... | Big Biker / ... (2 episodes, 2009-2011) |
| Lou Pimber | ... | Cartel Henchman (2 episodes, 2011) |
| Matt Berlin | ... | DEA Agent (2 episodes, 2011) |
| Dana Cortez | ... | Anchor #4 / ... (2 episodes, 2009-2010) |
| Adam Godley | ... | Elliot Schwartz / ... (2 episodes, 2008-2013) |
| Joe Nemmers | ... | DEA Agent Scott (2 episodes, 2013) |
| David Priemazon | ... | DEA Point Man / ... (2 episodes, 2009-2013) |
| J. Taylor | ... | Cop / ... (2 episodes, 2010-2011) |
| Kevin Christopher Brown | ... | APD Officer / ... (2 episodes, 2009-2010) |
| Michael-David Aragon | ... | DEA Agent (2 episodes, 2008-2009) |
| Tavia Schwartz | ... | Bad Girl / ... (2 episodes, 2008-2009) |
| Robert Anthony Brass | ... | Bank Customer / ... (2 episodes, 2008) |
| Grizelda Quintana | ... | Car Wash Attendant (2 episodes, 2011 |